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Ammit April 2018
FallenShadows714 April 2018

Help me out

Lethal Genes and GMT Lab

FallenShadows714 Apr 3, 2018 11:22 AM

I know some genes are lethal when homozygous (infamous frame and splash 2 being two of my favorites that are lethal homozygous). But, if it is lethal when homozygous, how are we able to make a create foundation horse have these genes homozygously? For example, my favorite foundation stud right now, Freaky Dreamer, was GMT’d to be homozygous Splash 2. Is this similar to the reason we can have the Freaky Friday horses with homozygous frame, that since it is a create horse we can do things that would normally create a lethal foal? Or is there a secondary factor, like the WF, that allowed the homozygous splash 2 that I just completely overlooked? I will link my example, Freaky Dreamer.
FallenShadows714 Apr 3, 2018 11:23 AM

My example

Freaky Dreamer G1
Ammit Apr 3, 2018 11:43 AM

They are lethal because the foal can not properly develop. That is not the same as genetically altering a functional adult animal to only pass on a certain allele.

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FallenShadows714 Apr 3, 2018 11:50 AM

Thank you Ammit, I figured it was something like that. I just wanted to be sure before I did any major alterations.

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